DNA SYNTHESIS AND CHROMOSOMAL ASYNCHRONY

Dna Synthesis and Chromosomal Asynchrony

A number of studies investigating the chronology of D N A synthesis in human chromosomes have indicated a degree of asynchrony among the members of the complement. The most striking asynchrony of D N A synthesis demonstrated within pairs of human chromosomes is the late replication of one of the X chromosomes shown by pulse labeling with tritiated thymidine in cultures of leucocytes (3, 4, 7, 8...

Asynchrony of Dna Synthesis in Chromosomes of Human Diploid Cells

It has been previously demonstrated (1) that the length of the period of DNA synthesis (S period) as measured by uptake of tritiated thymidine is approximately the same in several animal cells. Since the length of this period (with a range of 6/~ to 8 hours) appears to be independent of the species of the cell, the chromosome number, the cells of human diploid strains in long term cultivation.

Chromosomal Dna Synthesis in Drosophila Melanogaster

Analysis of labeling patterns in three chromosome segments of Drosophila melanogaster has shown that the replicative activity within chromosomes is temporally ordered. Moreover, specific labeling patterns on one chromosome occur with specific patterns on another chromosome with a very high degree of correlation. This circumstance leads to the conclusion that DNA synthesis among all the regions ...

Chromosomal abnormality, megaloblastosis, and arrested DNA synthesis in erythroleukaemia.

Chromosomal studies of bone-marrow cells have been reported on 30 patients with erythroleukaemia (Table I). Some of these reports give only meagre cytogenetic details, but there was an increased degree of polyploidy in at least 9 of the patients, significant aneuploidy in 12, and structural abnormalities in 11. Some patients showed more than one of these features, and only 8 patients had normal...

Characterization of Avian Pasteurella multocida Isolates by Protein Profiles and Restriction Enzyme Analysis of Chromosomal DNA